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Ana Maria VLADAREANU

Latest posts by Ana Maria VLADAREANU (see all)

Articole semnate de acelasi autor in Revista Practica Medicala:

De novo hepatitis B infection in a HBsAg-negative patient with chronic lymphoproliferative disorder

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Romanian Journal of Medical Practice | Vol. IX, No. 1 (33), 2014
ISSN 1842-8258  |  e-ISSN 2069-6108
ISSN-L 1842-8258
DOI: 10.37897/RJMP

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HIGHLIGHTS

National Awards “Science and Research”

NEW! RJMP has announced the annually National Award for "Science and Research" for the best scientific articles published throughout the year in the official journal.

ICMJE- Recommendations

Read the Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly work in Medical Journals.

Promoting Global Health

The published medical research literature is a global public good. Medical journal editors have a social responsibility to promote global health by publishing, whenever possible, research that furthers health worldwide.

De novo hepatitis B infection in a HBsAg-negative patient with chronic lymphoproliferative disorder

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ABSTRACT

HBV reactivation is becoming an important cause of morbidity and mortality in patients with hematologic malignancies undergoing chemotherapy, at highest risk being HBsAg positive patients (active or inactive chronic HBV infection). The occult carriers of HBV have a lower risk, but recent data reveal that reactivation risk is increasing and complications like fulminant hepatic failure and even death can occur. Pre-emptive antiviral therapy is the current standard for HBs Ag positive patients, but for occult carriers routine antiviral prophylaxis is recommended only in certain circumstances.

We report a case of „de novo“ hepatitis B in a patient with non-Hodgkin’s lymphoma and an unknown occult carrier status, which experienced viral reactivation after 5 month of combined fludarabine therapy. Lamivudine was initiated when HBs Ag seroreversion occurred and the outcome was good; she was then able to continue chemotherapy with rituximab-based regimen, maintaining antiviral treatment.

Keywords: screening, de-novo hepatitis B, occult HBV infection, lymphoma

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Human T lymphotropic virus related adult T-cell leukemia / lymphoma – presentation, prognosis and treatment. Case report

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Romanian Journal of Medical Practice | Vol. IX, No. 1 (33), 2014
ISSN 1842-8258  |  e-ISSN 2069-6108
ISSN-L 1842-8258
DOI: 10.37897/RJMP

Indexed

DOI - Crossref
Similarity Check by iThenticate, worldwide No 1 professional plagiarism checking system
DOAJ
Scopus
NLM Catalog
Ebsco Host - Medline
Semantic Scholar

HIGHLIGHTS

National Awards “Science and Research”

NEW! RJMP has announced the annually National Award for "Science and Research" for the best scientific articles published throughout the year in the official journal.

ICMJE- Recommendations

Read the Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly work in Medical Journals.

Promoting Global Health

The published medical research literature is a global public good. Medical journal editors have a social responsibility to promote global health by publishing, whenever possible, research that furthers health worldwide.

Human T lymphotropic virus related adult T-cell leukemia / lymphoma – presentation, prognosis and treatment. Case report

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ABSTRACT

We present the case of a patient diagnosed in SUUB Hematology with adult T-cell leukemia-lymphoma. The particularities of this case are the delay in diagnosis, the apparent onset of disease with severe eye and skin determination in the leukemic phase, and the particular lung involvement in the final stage of the disease.

Keywords: ATLL, HTLV1

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Femoral bone relapse in adult acute lymphoblastic leukemia Philadelphia chromosome positive: a case report

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Romanian Journal of Medical Practice | Vol. IX, No. 4 (37), 2014
ISSN 1842-8258  |  e-ISSN 2069-6108
ISSN-L 1842-8258
DOI: 10.37897/RJMP

Indexed

DOI - Crossref
Similarity Check by iThenticate, worldwide No 1 professional plagiarism checking system
DOAJ
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Ebsco Host - Medline
Semantic Scholar

HIGHLIGHTS

National Awards “Science and Research”

NEW! RJMP has announced the annually National Award for "Science and Research" for the best scientific articles published throughout the year in the official journal.

ICMJE- Recommendations

Read the Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly work in Medical Journals.

Promoting Global Health

The published medical research literature is a global public good. Medical journal editors have a social responsibility to promote global health by publishing, whenever possible, research that furthers health worldwide.

Femoral bone relapse in adult acute lymphoblastic leukemia Philadelphia chromosome positive: a case report

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ABSTRACT

We present a case of a 39-year-old male patient diagnosed with Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL) who relapse in unusual extramedullary site like bone. The patient was admitted complaining of intense pain in the left thigh 1 year following complete remission. Magnetic resonance imaging (MRI) revealed abnormal multifocal involvement in the left femur suggested malignancy. Bone marrow aspiration indicated recurrence of leukemic cells. These findings suggested bone relapse occurred simultaneously with medullary relapse.

Keywords: acute lymphoblastic leukemia, Philadelphia chromosome, bone relapse

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Particularitati de management al unui caz de purpura trombocitopenica imuna supraacuta în sarcina, finalizat cu splenectomie

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Romanian Journal of Medical Practice | Vol. X, No. 1 (38), 2015
ISSN 1842-8258  |  e-ISSN 2069-6108
ISSN-L 1842-8258
DOI: 10.37897/RJMP

Indexed

DOI - Crossref
Similarity Check by iThenticate, worldwide No 1 professional plagiarism checking system
DOAJ
Scopus
NLM Catalog
Ebsco Host - Medline
Semantic Scholar

HIGHLIGHTS

National Awards “Science and Research”

NEW! RJMP has announced the annually National Award for "Science and Research" for the best scientific articles published throughout the year in the official journal.

ICMJE- Recommendations

Read the Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly work in Medical Journals.

Promoting Global Health

The published medical research literature is a global public good. Medical journal editors have a social responsibility to promote global health by publishing, whenever possible, research that furthers health worldwide.

Particularitati de management al unui caz de purpura trombocitopenica imuna supraacuta în sarcina, finalizat cu splenectomie

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REZUMAT

Splenectomia este o manevră terapeutică cu indicaţie pentru o mare listă de afecţiuni, în principal hematologice. Dintre acestea, putem enumera anomaliile liniei eritrocitare: anemia hemolitică, sferocitoza ereditară sau talasemia, care au indicaţie de splenectomie în urma eşecului tratamentului medicamentos. O varietate de afecţiuni trombocitopenice sunt îmbunătăţite în urma splenectomiei, cea mai frecventă indicaţie fiind purpura trombocitopenică imună (PTI). Splenectomia la aceste grupe de pacienţi comportă un risc de infecţii fulminante, letale, care pot fi evitate cu tratamentul profilactic corespunzător. Cu toate că splenectomia în PTI nu are rol curativ, neîndepărtând sursa injuriei autoimune, aceasta conduce la îmbunătăţirea simptomelor, îmbunătăţirea valorilor trombocitelor, cu lipsa necesităţii unui tratament imunosupresor ulterior şi îmbunătăţirea calităţii vieţii.

Cuvinte cheie: splenectomie, splenectomie laparoscopică, purpură trombocitopenică imună, PTI, purpură trombocitopenică imună în sarcină

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Importanta clinica a modularii tratamentului cu Voriconazol în cazul aspergilozei pulmonare invazive pentru doua cazuri de leucemie acuta mieloblastica

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Romanian Journal of Medical Practice | Vol. X, No. 1 (38), 2015
ISSN 1842-8258  |  e-ISSN 2069-6108
ISSN-L 1842-8258
DOI: 10.37897/RJMP

Indexed

DOI - Crossref
Similarity Check by iThenticate, worldwide No 1 professional plagiarism checking system
DOAJ
Scopus
NLM Catalog
Ebsco Host - Medline
Semantic Scholar

HIGHLIGHTS

National Awards “Science and Research”

NEW! RJMP has announced the annually National Award for "Science and Research" for the best scientific articles published throughout the year in the official journal.

ICMJE- Recommendations

Read the Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly work in Medical Journals.

Promoting Global Health

The published medical research literature is a global public good. Medical journal editors have a social responsibility to promote global health by publishing, whenever possible, research that furthers health worldwide.

Importanta clinica a modularii tratamentului cu Voriconazol în cazul aspergilozei pulmonare invazive pentru doua cazuri de leucemie acuta mieloblastica

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REZUMAT

Introducere. Pacienţii cu leucemie acută reprezintă categoria de pacienţi cu neoplazii hematologice cu risc mare de dezvoltare a infecţiilor fungice invazive, iar agentul patogen frecvent implicat este Aspergillus spp.

Scop. Cele două cazuri prezentate îşi propun ilustrarea importanţei individualizării algoritmului de diagnostic şi tratament al infecţiilor fungice invazive la pacienţii cu leucemie acută pentru obţinerea unui răspuns optimal la tratamentul antifungic.

Material şi metodă. Prezentăm două cazuri de leucemie acută la pacienţi tineri, care dezvoltă aspergiloză pulmonară invazivă în cursul perioadei de neutropenie severă postchimioterapie. Diagnosticul se bazează pe criterii clinice, pe probe micologice pozitive, dar mai ales pe criterii imagistice, care au evidenţiat aspecte înalt sugestive pentru aspergiloză pulmonară invazivă şi astfel au determinat iniţierea promptă a tratamentului antifungic.

Concluzii. Cele două cazuri ilustrează evoluţia favorabilă a pacienţilor cu leucemie acută şi aspergiloză pulmonară invazivă în contextul tratamentului cu Voriconazol iniţiat prompt şi importanţa ajustării dozelor în funcţie de evoluţia clinică.

Cuvinte cheie: aspergiloză pulmonară invazivă, leucemie acută, Voriconazol

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Valoarea prognostica a markerilor traditionali si a biomarkerilor în leucemia limfatica cronica în practica clinica

SELECT ISSUE

Romanian Journal of Medical Practice | Vol. X, No. 1 (38), 2015
ISSN 1842-8258  |  e-ISSN 2069-6108
ISSN-L 1842-8258
DOI: 10.37897/RJMP

Indexed

DOI - Crossref
Similarity Check by iThenticate, worldwide No 1 professional plagiarism checking system
DOAJ
Scopus
NLM Catalog
Ebsco Host - Medline
Semantic Scholar

HIGHLIGHTS

National Awards “Science and Research”

NEW! RJMP has announced the annually National Award for "Science and Research" for the best scientific articles published throughout the year in the official journal.

ICMJE- Recommendations

Read the Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly work in Medical Journals.

Promoting Global Health

The published medical research literature is a global public good. Medical journal editors have a social responsibility to promote global health by publishing, whenever possible, research that furthers health worldwide.

Valoarea prognostica a markerilor traditionali si a biomarkerilor în leucemia limfatica cronica în practica clinica

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REZUMAT

Leucemia limfatică cronică este o boală cu evoluţie naturală îndelungată, care beneficiază de o terapie cu eficienţă redusă şi foarte rar de răspuns complet la tratament. Tot mai mulţi pacienţi sunt diagnosticaţi în stadii asimptomatice şi la vârste tot mai tinere. Progresele recente în descoperirea mecanismelor moleculare implicate în patogeneza bolii, însoţite de apariţia de noi agenţi terapeutici, lansează o provocare continuă pentru clinicieni în stabilirea conduitei terapeutice la aceşti pacienţi. În paralel, au fost realizate studii pentru a evidenţia acei factori care influenţează efectiv răspunsul terapeutic şi durata acestuia – markerii de prognostic, în scopul adoptării unei strategii terapeutice cât mai adaptate la caz. Deşi stadializarea clinică rămâne baza pentru evaluarea prognosticului în leucemia limfatică cronică, o serie de markeri biologici, în special markeri serici, anomaliile citogenetice, statusul mutaţional IgVH, expresia CD38 şi ZAP-70 în celulele leucemice, oferă informaţii prognostice importante şi independente. Înainte de a fi încorporaţi în practica clinică de zi cu zi, aceşti markeri necesită însă standardizare şi validare în studii prospective mai mari. În prezent se încearcă combinarea acestor markeri prognostici pentru a obţine un sistem integrat de stratificare a riscului, cu largă aplicabilitate clinică.

Cuvinte cheie: leucemie limfatică cronică, markeri de prognostic, biomarkeri

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