SELECT ISSUE

Romanian Journal of Medical Practice | Vol. IX, No. 1 (33), 2014
ISSN 1842-8258  |  e-ISSN 2069-6108
ISSN-L 1842-8258
DOI: 10.37897/RJMP

Indexed

DOI - Crossref
Similarity Check by iThenticate, worldwide No 1 professional plagiarism checking system
DOAJ
Scopus
NLM Catalog
Ebsco Host - Medline
Google Academic
Semantic Scholar

HIGHLIGHTS

National Awards “Science and Research”

NEW! RJMP has announced the annually National Award for "Science and Research" for the best scientific articles published throughout the year in the official journal.

ICMJE- Recommendations

Read the Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly work in Medical Journals.

Promoting Global Health

The published medical research literature is a global public good. Medical journal editors have a social responsibility to promote global health by publishing, whenever possible, research that furthers health worldwide.

De novo hepatitis B infection in a HBsAg-negative patient with chronic lymphoproliferative disorder

, , , , , and

ABSTRACT

HBV reactivation is becoming an important cause of morbidity and mortality in patients with hematologic malignancies undergoing chemotherapy, at highest risk being HBsAg positive patients (active or inactive chronic HBV infection). The occult carriers of HBV have a lower risk, but recent data reveal that reactivation risk is increasing and complications like fulminant hepatic failure and even death can occur. Pre-emptive antiviral therapy is the current standard for HBs Ag positive patients, but for occult carriers routine antiviral prophylaxis is recommended only in certain circumstances.

We report a case of „de novo“ hepatitis B in a patient with non-Hodgkin’s lymphoma and an unknown occult carrier status, which experienced viral reactivation after 5 month of combined fludarabine therapy. Lamivudine was initiated when HBs Ag seroreversion occurred and the outcome was good; she was then able to continue chemotherapy with rituximab-based regimen, maintaining antiviral treatment.

Keywords: screening, de-novo hepatitis B, occult HBV infection, lymphoma

Full text | PDF

Leave a Reply