Romanian Journal of Medical Practice | Vol. IX, No. 4 (37), 2014
ISSN 1842-8258  |  e-ISSN 2069-6108
ISSN-L 1842-8258
DOI: 10.37897/RJMP


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Femoral bone relapse in adult acute lymphoblastic leukemia Philadelphia chromosome positive: a case report

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We present a case of a 39-year-old male patient diagnosed with Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL) who relapse in unusual extramedullary site like bone. The patient was admitted complaining of intense pain in the left thigh 1 year following complete remission. Magnetic resonance imaging (MRI) revealed abnormal multifocal involvement in the left femur suggested malignancy. Bone marrow aspiration indicated recurrence of leukemic cells. These findings suggested bone relapse occurred simultaneously with medullary relapse.

Keywords: acute lymphoblastic leukemia, Philadelphia chromosome, bone relapse

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