Arhiva autor

Nicolae BACALBASA

Latest posts by Nicolae BACALBASA (see all)

Articole semnate de acelasi autor in Revista Practica Medicala:

Current status and novel directions in triple negative breast cancer patients. Risk factors. Role of the platinum-based chemotherapy

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Romanian Journal of Medical Practice | Vol. XI, No. 2 (45), 2016
ISSN 1842-8258  |  e-ISSN 2069-6108
ISSN-L 1842-8258
DOI: 10.37897/RJMP

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National Awards “Science and Research”

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ICMJE- Recommendations

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Promoting Global Health

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Current status and novel directions in triple negative breast cancer patients. Risk factors. Role of the platinum-based chemotherapy

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ABSTRACT

Rationale. Breast cancer (BC) has been recognized to be the most common type of cancer in women all over the world. One of the most aggressive subtype of BC is the triple negative breast cancer (TNBC) which
is defined by the absence of estrogen receptor (ER) and progesterone receptor (PR) as well as the lack of overexpression of the human epidermal growth factor 2 (HER 2).
Aim. As the estrogen and progesterone receptors as well as the expression of HER2 are lacking, a targeted therapy with anti-hormone agents and anti-HER2 cannot be utilized, the therapeutic possibilities for TNBC women are limited. The aim of this review is to present the current scientific data as well as the latest research in TNBC with focus on the risk factors as well as the current role of platinum-based chemotherapeutic agents and their future implications in TNBC treatment.
Method. Information about the risk factors associated to TNBC as well as the chemotherapeutic regimens was searched through Pubmed and Medline using controlled vocabulary (e.g. breast cancer) and key words (e.g. neoadjuvant, triple negative, platinum). Systematic reviews, randomized and controlled clinical trials were analyzed. No restrictions regarding date or language were used.
Conclusions. TNBC is a complex and heterogeneous disease, divided into many subtypes and with an aggressive evolution. Premenopausal women and African American women are far more likely to develop
TNBC. More research is required in order to confirm the association between obesity, BMI, parity, use of oral contraceptives, alcohol and cigarette smoking and TNBC. Randomized clinical trials presented at the
San Antonio Symposium suggest that platinum chemotherapy play an important role in the treatment of TNBC, especially early stage TNBC. Tumor-based measures of genomic instability will help to clarify the
optimal use and activity of platinum in TNBC. However, it is clear than more epidemiological studies as well as the discovery of novel therapeutic possibilities are mandatory in order to unravel the complexity of
this BC subtype, hence offering a chance to women diagnosed with TNBC.

Keywords: breast cancer, triple negative, platinum, neoadjuvant

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Colorectal neuroendocrine tumors

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Romanian Journal of Medical Practice | Vol. XI, No. 2 (45), 2016
ISSN 1842-8258  |  e-ISSN 2069-6108
ISSN-L 1842-8258
DOI: 10.37897/RJMP

Indexed

DOI - Crossref
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DOAJ
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NLM Catalog
Ebsco Host - Medline
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HIGHLIGHTS

National Awards “Science and Research”

NEW! RJMP has announced the annually National Award for "Science and Research" for the best scientific articles published throughout the year in the official journal.

ICMJE- Recommendations

Read the Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly work in Medical Journals.

Promoting Global Health

The published medical research literature is a global public good. Medical journal editors have a social responsibility to promote global health by publishing, whenever possible, research that furthers health worldwide.

Colorectal neuroendocrine tumors

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ABSTRACT

Gastrointestinal neuroendocrine tumors originate from amine precursor uptake and decarboxylation cells in the digestive tract and have the ability to undergo multiple differentiation and secrete various active
hormones, leading to significant differences in biological behaviors and prognosis. Previous studies have indicated a low incidence rate, but recently epidemiological investigations in the USA showed that the incidence rate was significantly higher. Gastrointestinal neuroendocrine tumors have received much attention in recent years with regard to their diagnosis, classification, prognosis and treatment.

Keywords: neuroendocrine tumors, gastrointestinal tract, colorectal cancer, carcinoid

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Tumor markers in heart failure

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Romanian Journal of Medical Practice | Vol. XI, No. 1 (43), 2016
ISSN 1842-8258  |  e-ISSN 2069-6108
ISSN-L 1842-8258
DOI: 10.37897/RJMP

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National Awards “Science and Research”

NEW! RJMP has announced the annually National Award for "Science and Research" for the best scientific articles published throughout the year in the official journal.

ICMJE- Recommendations

Read the Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly work in Medical Journals.

Promoting Global Health

The published medical research literature is a global public good. Medical journal editors have a social responsibility to promote global health by publishing, whenever possible, research that furthers health worldwide.

Tumor markers in heart failure

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ABSTRACT

It has been widely demonstrated that patients diagnosed with chronic heart failure present high levels of circulating neurohormones and inflammation markers which can secondarily induce an increase of the level of tumor markers such as CA 125, AFP, CEA, CA 15.3 or CA 19-9. This is a literature review regarding the benefits of determination of tumor markers serum levels in cases presenting chronic heart failure.

Keywords: chronic heart failure, CA 125, CA 15.3, CEA

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Sentinel lymph node in early cervical cancer – pros and cons aspects

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Romanian Journal of Medical Practice | Vol. X, No. 4 (42), 2015
ISSN 1842-8258  |  e-ISSN 2069-6108
ISSN-L 1842-8258
DOI: 10.37897/RJMP

Indexed

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HIGHLIGHTS

National Awards “Science and Research”

NEW! RJMP has announced the annually National Award for "Science and Research" for the best scientific articles published throughout the year in the official journal.

ICMJE- Recommendations

Read the Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly work in Medical Journals.

Promoting Global Health

The published medical research literature is a global public good. Medical journal editors have a social responsibility to promote global health by publishing, whenever possible, research that furthers health worldwide.

Sentinel lymph node in early cervical cancer – pros and cons aspects

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ABSTRACT

Cervical cancer remains an important health problem worldwide responsible for a high number of deaths especially in cases diagnosed in advanced stages. When it comes to patients diagnosed in early stages, they have an improved prognosis with high rates of 5 year overall survival. Due to the fact that one of the most important routes of dissemination remains the lymphatic pattern, studies were focused on determining which cases are more suitable for lymph node dissection even if an early stage of the disease is expected. This is a literature review regarding pros and cons aspects of the utility of sentinel lymph node in early stage cervical cancer.

Keywords: early stage, cervical cancer, sentinel lymph node, lymph node dissection

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Prostate cancer tumor markers

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Romanian Journal of Medical Practice | Vol. X, No. 3 (40), 2015
ISSN 1842-8258  |  e-ISSN 2069-6108
ISSN-L 1842-8258
DOI: 10.37897/RJMP

Indexed

DOI - Crossref
Similarity Check by iThenticate, worldwide No 1 professional plagiarism checking system
DOAJ
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Ebsco Host - Medline
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HIGHLIGHTS

National Awards “Science and Research”

NEW! RJMP has announced the annually National Award for "Science and Research" for the best scientific articles published throughout the year in the official journal.

ICMJE- Recommendations

Read the Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly work in Medical Journals.

Promoting Global Health

The published medical research literature is a global public good. Medical journal editors have a social responsibility to promote global health by publishing, whenever possible, research that furthers health worldwide.

Prostate cancer tumor markers

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ABSTRACT

Prostatic cancer represents an important health problem worldwide, being the third most common malignancy in men older than 55 years, after pulmonary and colon cancer. In early stages prostatic cancer remains hard to be diagnosed at clinical or imagistical studies, the most efficient way to detect it being based on the determination of tumor markers. This is a literature review of the largest studies conducted on the theme of prostatic tumor markers.

Keywords: prostate cancer, prostate specific antigen, prostate health index, prostate cancer gene

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Therapeutic strategies in primary malignancies of the vagina – a literature review

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Romanian Journal of Medical Practice | Vol. X, No. 1 (38), 2015
ISSN 1842-8258  |  e-ISSN 2069-6108
ISSN-L 1842-8258
DOI: 10.37897/RJMP

Indexed

DOI - Crossref
Similarity Check by iThenticate, worldwide No 1 professional plagiarism checking system
DOAJ
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HIGHLIGHTS

National Awards “Science and Research”

NEW! RJMP has announced the annually National Award for "Science and Research" for the best scientific articles published throughout the year in the official journal.

ICMJE- Recommendations

Read the Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly work in Medical Journals.

Promoting Global Health

The published medical research literature is a global public good. Medical journal editors have a social responsibility to promote global health by publishing, whenever possible, research that furthers health worldwide.

Therapeutic strategies in primary malignancies of the vagina – a literature review

, and

ABSTRACT

Primary vaginal cancers are very rare malignancies accounting for only 1 to 2% of all gynecologic malignancies. The most frequent histologic subtype is squamous cell carcinoma followed by adenocarcinoma. Due to its rarity, data concerning the natural history, prognostic factors, and treatment are rather poor; however an extension of the reported clinical experience for cervical and anal cancer has been proposed given the similarities in disease etiology and the desire for organ preservation. This is a literature review of the most appropriate therapeutic strategies used in vaginal cancer management.

Keywords: vaginal cancer, squamous cell carcinoma, radiation therapy

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The surgical treatment of thoracic metastases in ovarian cancer

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Romanian Journal of Medical Practice | Vol. X, No. 2 (39), 2015
ISSN 1842-8258  |  e-ISSN 2069-6108
ISSN-L 1842-8258
DOI: 10.37897/RJMP

Indexed

DOI - Crossref
Similarity Check by iThenticate, worldwide No 1 professional plagiarism checking system
DOAJ
Scopus
NLM Catalog
Ebsco Host - Medline
Semantic Scholar

HIGHLIGHTS

National Awards “Science and Research”

NEW! RJMP has announced the annually National Award for "Science and Research" for the best scientific articles published throughout the year in the official journal.

ICMJE- Recommendations

Read the Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly work in Medical Journals.

Promoting Global Health

The published medical research literature is a global public good. Medical journal editors have a social responsibility to promote global health by publishing, whenever possible, research that furthers health worldwide.

The surgical treatment of thoracic metastases in ovarian cancer

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ABSTRACT

Ovarian cancer still represents one of the most aggressive malignancies affecting women worldwide. Unfortunately many patients are still diagnosed in an advanced stage of the disease when distal metastases are already present. When it comes to thoracic involvement in advanced stage ovarian cancer, this may develop via peritoneal, hematogenous and lymphatic route. This is a literature review of the most commonly seen involvements in ovarian cancer and of the most appropriate surgical procedures which might be performed in order to increase the rate of complete cytoreduction.

Keywords: advanced stage ovarian cancer, peritoneal seeding, metastasectomy, diaphragmatic resection, supradiaphragmatic lymphadenectomy

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